It appears clearly that it is approximately linear on a significant range of STO values and can therefore be used efficiently to perform the STO estimation.
There was no significant difference between structures (F = 1.91, p = 0.09, df = 5, 257; none of the post-hoc analyses were significant: range of p values = 0.22 - 1.00), suggesting that there is no systematic bias.
However, further examination of the data of McEvoy et al (2009; GEonGSE29683) on 52 human retinoblastomas suggests that there is a significant range of expression values for individual retinal cell type-specific genes in this large complex data set (Supplementary Figure S4).
There was no significant difference in standard error between structures (F = 1.91, p = 0.09, df = 5, 257; none of the post-hoc analyses were significant: range of p-values = 0.22 1.00), suggesting that there is no systematic bias.
Fourthly, and as a result, a diversity of mutational pathways leading to a variety of patterns of complex modulation become available to Darwinian evolution thus leading to efficient protein adaptation within some evolutionarily significant range of protein property values.
Furthermore, we found that the other two criteria are extremely robust: random addition and deletion of up to 15% of the edges has no appreciable effect on the statistically significant ranges of cutoff values for all four networks (data not shown).
Overall, it can be seen that the local-score SCPE performs somewhat better than the global-score SCPE, and that both SCPE models clearly outperform JTT for a significant range of parameter ω around the optimum value.
Data were analyzed using the two-tailed Student's paired t-test of compound treated cells vs. DMSO treated cells with P-values within statistically significant range of P < 0.0001 and P < 0.008.
The risk of being in the lowest intelligence centile associated conferred by the CC genotype also remained significant across the same range of values for both the additive and dominant models; below average intelligence (p = 0.044additive, p = 0.012dominant);lowest 40th centile (p = 0.036additive, p = 0.008dominant); lowest 30th centile (p = 0.016additive, p = 0.008dominant).
There is a significant narrowing in the range of values giving a good fit, for the interaction between r c and μ2 as well as for the ratio between μ2 and σ2.
