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Yet, significant puzzles remain, and a clear picture of the Rev-RRE-Crm1 complex that exports the viral RNA from the host cell nucleus has yet to emerge.
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The emergence of polypeptide catalysts for amino acid activation, the slowest step in protein synthesis, poses a significant puzzle associated with the origin of biology.
A significant puzzle that has occupied the scholarship on the commons concerns (1) the differences between formally designed and introduced institutions vs. self-organized informal network norms, and 2) the effects of these differences on resources and governance outcomes.
In the early years of the modern scientific era, the source of the Sun's energy was a significant puzzle.
There is however a significant variation across puzzles when considering the two other measures, related to the reactivity of the crowd.
"These parcels are not a significant piece of this puzzle," Mr. Ruth said.
There have been some notable steps forward in recent years when it comes to opening up these issues, but to me there is still a significant piece of the puzzle missing.
Here's how.
Still, the college essay is a highly significant piece of the puzzle in that it is one of the only opportunities students have to speak to admissions officers in their own voices and highlight something about their personalities or passions that allows them to stand our from other, similarly qualified candidates.
A significant piece of the puzzle lies in finding a molecular mechanism or marker for rotation resistance.
In spite of significant progress, the pathogenic puzzle stands unsolved and HD remains as incurable now as upon the time of George Huntington's first report over a century ago.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com