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Wiggins spent a significant proportion of stage seven on his own, marking a stark contrast from the massed ranks which saw him to victory in last year's Tour de France.
Surgical resection is highly effective in localised disease, but a significant proportion of stage II patients (20 25%) experiences recurrence and dies from the disease.
However, tumours within the same stage are biologically and molecularly heterogeneous, and a significant proportion of stage II patients develop metastatic disease despite apparently curative surgery [ 4, 5].
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Infection with HCV may lead to disabling symptoms, cirrhosis and hepatocellular carcinoma [ 3, 4] and is said to account for a significant proportion of end-stage liver disease among HCV-infected individuals (incidence of 3.1 per 1000 person-years) [ 5].
To date, the disease has only been reported in individuals from Cyprus, where it is an endemic cause of renal disease and accounts for a significant proportion of end-stage kidney failure on the island (Athanasiou et al., 2011).
Overall, a significant proportion of TFs showed stage-specific expression.
Male patients had a significant proportion of advanced tumor stages (pT2-4 > 60%) and more than 40% showed nodal involvement [ 25].
A significant proportion of cancer patients at all stages of the disease trajectory will suffer social, emotional and psychological distress as a result of cancer diagnosis and treatment.
Despite improvements in the early detection of gastric cancer, a significant proportion of patients present with inoperable stages where chemotherapy is required.
A significant proportion of patients initially diagnosed with early-stage breast cancer ultimately progress to metastatic disease.
Unlike to our study, other studies have also found that a significant proportion of patients died in the early stages of treatment [ 21, 22].
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com