Sentence examples for significant problem was from inspiring English sources

Each significant problem was required to be reported to the F.D.A., but the company failed to do so.

A significant problem was Wright's libretto, which didn't come close to Hitchcock's adaptation in terms of making something dramatically viable out of Winston Graham's 1961 book.

One significant problem was that the fire knocked out the radio system, which had no backup power supply, leaving a crew member to call for help on his cellphone.

The most significant problem was reported as the loss of agriculture (57.1%).

The most significant problem was the lack of airfoil experimental data in scientific literature, above all at very low Reynolds numbers.

An additional significant problem was the excess release of dopamine by the transplanted tissue, leading to dystonias.

"The significant problem is uncertainty above all," she said.

Another significant problem is that the majority returns this case to the circuit court for a recount with no standards.

An even more significant problem is that utilities increasingly face opposition to expansion and must fight for years for permits.

The most significant problem is its significant BOD content ranging from 35,000 55,000 mg/L.

I suppose the only significant problem is that at least one Test-playing nation would only get one game.