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The results revealed that MPP patients exhibit significant poorer performances, in comparison to the DPP, IPP, and HC groups in alternating attention, verbal fluency, and delayed memory.
Furthermore, DPP patients did not exhibit, in none of the seven neuropsychological tests, significant poorer performances than MPP or IPP patients, although having significant more episodes than MPP patients.
Furthermore, DPP patients did not exhibit, in none of the seven neuropsychological tests, significant poorer performances than MPP or IPP patients, suggesting that DPP patients who participated in the study are possibly less affected by neuroprogression than MPP and IPP patients.
Specifically, as shown in the Kaplan-Meier plots of Figure 6B, significant poorer outcome in disease free survival (DFS; P = 0.004227 and P = 0.005694) were observed between Stockholm patients with a higher EZH2 and a lower CDKN1C, respectively.
Patients with advanced pT stage had a significant poorer survival in multivariate analysis (P=0.038).
Chromosome 1p deletion was not associated with statistically significant poorer EFS and OS.
Similar(32)
They reported that the 5-year survival after metastasectomy was 50%, and metastasis exceeding 3 cm in size was proven to be a significant poor prognostic factor on a multivariate analysis [7].
For Ki67 and p53, higher levels of expression showed a weak but significant poor prognostic effect whilst high bcl2 showed a weak but significant poor prognostic effect.
> 5 cm, extrathyroidal invasion, and distant metastasis were revealed to be significant poor-prognosis factors [ 8].
Age ≥ 60 years was also a significant poor prognostic factor for OS (Table 5).
The expression of S1PR1 was a significant poor prognostic factor (p = 0.018; Figure 2C), while pSTAT3 expression was not.
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