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Furthermore, KEGG pathway analysis identified significant pathways that were mostly related to immunity and disease.
Pathway analysis identified significant pathways that were mostly related to nutrient metabolism, and the PPAR signalling pathway was also mapped, reaching significance (P < 0.05) (Table S7).
We were able to efficiently generate regulatory networks with statistically significant pathways that have been predicted previously.
Furthermore, we anticipated that breed-related gene expression profiles would uncover biologically and therapeutically significant pathways that would inform etiology and identify therapeutic targets.
Other significant pathways that have previously been implicated in heart development include ribosomal proteins [55], the actin cytoskeleton [52], Wnt signaling [56], and cytokine-cytokine receptor interaction [57].
The NJ data had two out of five significant pathways that overlapped pathways found when IL23R was included.
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Subsequent analyses show that gamma-glutamyltransferase (γ-GT) may be a significant pathway that resulted in the formation of glutamate and ammonia from glutamine catabolism extracellularly.
When we intersected the three pathway sets, we found one significant pathway that prevailed across the multiple data sets.
Table 1 shows the pathways found to be notable in all 11 of our analyses, and the most significant pathway that was not notable.
Although the most significant pathway that leads to CHOP induction is mediated through PERK, both the IRE1/XBP1 and ATF6 pathways contribute.
The most significant gene pathways that distinguish SF and SC fibrocytes include the immune and inflammatory response, chemotaxis, RNA processing and lipid metabolism pathways.
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