In E1A- HRAS G12V -transformed Craf −/− MEFs, dabrafenib fails to confer a significant growth advantage, suggesting that in the absence of significant paradoxical ERK activation, dabrafenib does not have a relevant off-target effect that results in a growth advantage.
The c-erbB-4 receptor expression showed a significant paradoxical association with ER status and local recurrence, while being significantly associated with poorer histological grade, higher lymph node stage, NPI and the presence of vascular invasion.
Our most prominent finding is that cessation of IABP-support resulted in a significant and paradoxical increase in small-vessel PVD, independent from initial disease severity.
Though the warmer air temperature within the UHI is generally most apparent at night, urban heat islands exhibit significant and somewhat paradoxical diurnal behavior.
Our studies reveal a complex pattern of changes in kainate receptor subunit expression induced by adrenalectomy and corticosteroid replacement and a significant and somewhat paradoxical effect of CRS and chronic corticosterone on KA1 mRNA levels, but no effect of CRS upon either KA2 mRNA levels or levels of GluR5-7 mRNA.
A better understanding of metabolic pathways and the effects of other anti-cancer agents on them may offer significant insight into paradoxical effects seen with many chemotherapeutic drugs.
In fetuses whose mothers consumed the low-phytoestrogen PMI 5K96 feed, we found a paradoxical significant elevation in endogenous serum estradiol, which was associated postnatally with adverse reproductive outcomes referred to as the "fetal estrogenization syndrome (FES)".
Moreover, noteworthy a paradoxical significant increase of the viral titer, at 48 hs post infection, for BoHV-4ΔIE1 infected BEK-boBST-2 cells supernatant respect to the supernatant of BoHV-4ΔIE1 infected BEK cells (Fig. 4d) was observed.
Accordingly, these patients in BCLC-C had a significant and theoretically paradoxical better survival (28 months) than patients in the BCLC-B stage (6 months), as all the latter had large tumors (diameter >5 cm) (Tables 2, 5).
Ventricular dyssynchrony results in deficient LV filling, slower rate of increase in LV contractile force, significant mitral regurgitation, paradoxical septal wall motion, and reduced cardiac output [ 32, 163] and has been associated with increased mortality in patients with systolic HF [ 164, 165].
In PE, a paradoxical and significant increase of circulating adiponectin of 30%to87%7% has been described in most [ 6, 13– 15] but not all studies [ 16, 17].
