Further, it was remarkable to note uniquely significant overrepresentation of the ribosomal pathway in females (Fig. 3).
Under these regions, 318 unique Ensembl genes are annotated with a significant overrepresentation of immune related pathways.
To explain the "overcorrection," analysis by maternal weight showed significant overrepresentation of IDDM patients at 175 pounds or above.
Further, our findings are confirmed by the analysis of curated database of protein complexes that showed highly statistically significant overrepresentation of dimers formed by structurally similar proteins with highly divergent sequences ("superfamily heterodimers").
Recently, a significant overrepresentation of C→G mutations in the Sp1 binding site in the non-coding control region (NCCR) of BKV was shown to be present in HC patients and absent in non-HC patients.
This family of genes correspondingly contains a significant overrepresentation of differentially methylated regions.
Analysis of related gene ontology terms did not reveal a significant overrepresentation of specific functional categories (data not shown).
In addition, IPA identified significant overrepresentation of genes associated with cancer, cell death, proliferation, glioblastomas, and astrocytomas.
The presence of lymphocyte aggregates dominated the expression profiles and a significant overrepresentation of lymphocyte aggregates in good responding patients confounded the analyses.
There is a highly significant overrepresentation of MREs for miR-29 in the mRNA sequences of the elastin and type 1 collagen genes throughout mammalian evolution.
Functionally, there is no significant overrepresentation of functional categories among the differentially expressed genes, although GSEA indicates increased levels of neutrophil-associated genes.
