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Regulatory issues pose a significant obstacle to the development of transgenics and their commercialization.
Flooding is a significant obstacle to the development of Bangladesh, which is home to two of the largest river systems in the world: the Brahmaputra and the Ganges.
(Such constant change makes it hard to develop antiviral drugs that will remain effective for long, and it has also presented a significant obstacle to the development of an AIDS vaccine).
Nevertheless, the arbitrary 34,000 daily quota is a significant obstacle to the development of true alternatives to detention and to the operation of detention centers that incorporate civil, nonpunitive detention standards.
While this has been touted for some years, surprisingly little progress has been made in this area and the absence of a satisfactory animal model is a significant obstacle to the development of a therapeutic vector.
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This is a significant obstacle to the continued development of the residential solar market.
The company hoped that by promoting hockey played on rollerblades rather than skates, it could overcome a significant obstacle to the sport's development in the United States: a lack of ice rinks.
Another significant obstacle to the acceptance of video telephone systems has been quality.
However, they do create a significant obstacle to the versatility of radiometalated bioconjugates.
A major obstacle to the development of education software is its enormous cost, said Mr. Heuston.
But a potential obstacle to the development of irrigation is the cost.
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