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However, it is clear that in spite of the qualitative and quantitative differences in the methodological approaches used to identify the gene complement of the cenancestor, the inventories show an overlap which reflects an impressive level of conservation of a significant number of sequences involved in basic biological processes.
In other words, our best results are for simulations which take into account a sufficiently significant number of sequences (twelve or nine sequences).
Results in Table 2 show that a significant number of sequences were identified from annotation associated with stress responses.
This results in a significant number of sequences deposited under erroneous or imprecise names, so-called 'dark taxa' (9, 10).
A significant number of sequences from the appressoria library were shorter than 16 nt and were eliminated from further consideration.
It is therefore likely that a significant number of sequences are anchored incorrectly in the version of the apple genome used here.
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Despite experimental procedures that we establish to enrich for RNA viruses, a significant number of sequence reads mapped to DNA viruses both ssDNA and dsDNA.
Second, the protein families represented in today's sequence databases are often more complex, with multidomain architectures, large unstructured (natively disordered) regions, numerous splicing variants, etc. Third, the new sequences are mostly predicted by automatic methods and thus, contain a significant number of sequence errors [33], [34].
In addition, due to the low genomic coverage, the degradation of the template DNA, and the innate error rate of the sequencing platforms [12], the paleogenomic data contains a significant number of sequencing errors, resulting in an excess of C to T substitutions due to cytosine deaminations as compared to the corresponding reference genome [3], [5], [9], [13].
However, there are also a significant number of sequence pairs whose profiles are of similar shape but offset by significant amounts (boxed region in Figure 4A).
We used M. tuberculosis H37Ra genome sequence as a reference strain for sequence comparison with the PZA-resistant mutants derived from M. tuberculosis H37Rv because of the significant number of sequencing errors in the original H37Rv genome sequence in the database.
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