That is, if two proteins have a significant number of common interacting partners in the network, then they have functional similarities and therefore also contribute to each other's expressions [ 52].
In the case of RMG 7 a significant number of direct interactions with the proliferation metagene were observed, with TP53 and PAFAH1B1 interacting with 17 proliferation metagenes components including CDC2, CCNA2, RAD51 and AURKA (Additional File 5).
A board of directors is only credible to the extent that a significant number of its members are able to interact knowledgeably with management on the multiple factors that influence performance.
A significant number of cytosolic localized proteins are predicted to interact with nuclear and mitochondrial localized proteins, indicating possible import/export regulation and dual localized proteins such as transcription factors.
Informally, given two biological processes, they defined the first process as being linked to the second process if genes annotated by the first process interact with a significant number of genes annotated by the second process.
Despite this low expression, ESC-expressed DDB1 was found to interact with a significant number of DCAF proteins, even more that the DCAF proteins identified in HL60 cells where exogenous expression was higher.
One can clearly see a significant number of the genes in this pathway in the largest network of interacting autism genes, suggesting that this pathway may indeed play a significant role in autism.
A significant number of respondents were interested in being provided resources for interacting with families, specifically information material (64.4% of respondents), secure communication systems with families (28.9%), personal health records (20.7%), and social communities with families (12.3%).
Thus, if there were a significant number of genes in GO category X altered on day d interacting with gene in GO category Y altered on day (d + 1), we hypothesize that a causative relation X - > Y.
Thus, if there were a significant number of genes of GO category X first altered on day d interacting with genes in GO category Y first altered on day (d+1), then we could hypothesize a causative relation (meta-flow) X→Y.
