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Recently, a significant number of functional retrocopies (i.e. retrogenes) have been identified in the genomes of mammals and insects [9], [10], [11], [12],, which raised the interest in studying the functional contribution from retroposition.
As stated above DHD remains asymptomatic for long time and when diagnosed at the late stage, a significant number of functional cardiomyocytes are replaced by fibroblasts.
These results lend credibility to the SVM predictions since the predictions share a significant number of functional categories with the training set.
55 of them are conserved across human, chimpanzee and macaque, suggesting that there are still a significant number of functional human genes absent from the human reference genome.
Our data show that poly(A) sites constituting an A-rich upstream sequence represent about 5 10% of the total poly(A) sites of each group, suggesting that upstream A-rich sequences represent a significant number of functional noncanonical poly(A) sites.
This resemblance to the ScACS motif is particularly important here as it may help explain our finding that L. kluyveri and S. cerevisiae have a much higher rate of mutual acceptance of ARSs than any one of them has with K. lactis, as well as explain the significant number of functional KlARSs they share.
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Pfam contains almost 15 000 curated protein families, while ELM contains less than 200 motif classes, suggesting that significant numbers of functional features are still to be identified and further annotation is required.
It is also apparent from the data illustrated in Fig. 2 and 3 that a significant number of oxygen containing functional groups are present in both the modern and fossil polymers.
Recently, a significant number of transcribed and functional retrocopies were discovered in the primate and rodent genome [ 11, 15, 26- 29], but there has not been any study of the expressed retrocopies in the teleostei genome.
For a significant number of adults the level of functional literacy is so low that they are not ready to study for qualifications.
Joint replacement registries report increasing numbers of TKR operations, which are projected to rise by 673% to 3.48 million procedures in the USA alone by 2030. 1 Although TKR is safe and effective, 2 3 a significant number of patients experience continued functional limitation after surgery.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com