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The phrase "significant negative effect" is correct and usable in written English.
It is used to describe a strong, unfavorable result or consequence of a given situation. For example: "The new policy has had a significant negative effect on employee morale."
Exact(60)
NH4NO3 has a significant negative effect.
Trees generally had a significant negative effect on maize yield.
In an extensive survey, economists Felipe Campante and David Yanagizawa-Drott show that Ramadan fasting has a significant negative effect on output growth in Muslim countries.
This illustrates that the weakness in the UK's major trading partners, which is also looking more entrenched, is now having a significant negative effect on the UK economy.
Sarah Brewer, a doctor and adviser to Atkins Nutritionals UK, says there is no scientific evidence that the Atkins diet has a significant negative effect on LDL cholesterol.
Bioenergy and food production had a significant negative effect on adult and fledgling skylarks.
Heat waves had a significant negative effect on biovolume, whereas turbidity tended to affect biovolume positively.
Experimental shading had a significant negative effect on plant survival and flowering performance.
Captions were found to have a significant negative effect on learner performance.
Food level only had a significant negative effect (***p<0.001) on R0.
We found a significant negative effect of forest land use on water costs.
More suggestions(15)
significant detrimental effect
noticeable negative effect
significant unfavorable effect
notable negative effect
significant harmful effect
tangible negative effect
significant downward effect
significant inverse effect
significant negative impact
significant negative feedback
significant negative correlation
significant protective effect
significant negative change
significant negative association
significant negative contribution
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com