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The phrase "significant negative change" is grammatically correct and can be used in written English.
You can use this phrase when describing a big or impactful decrease or deterioration in a situation or condition. Example: The company's profits experienced a significant negative change after the stock market crash.
Exact(13)
Significant negative change over time was observed for all cognitive and brain measures.
Conversely, a significant negative change in level was observed in 7 (26%) of the measures.
Accreditation was associated with a significant negative change in slope in 13 (48%) of the measures.
The "-" signs following numbers in this column denote variables with significant negative change.
Conversely, the Y 6 measure (turnaround time) decreased immediately post- accreditation survey with a significant negative change in slope (P ≤ 0.0001).
As a result of the NanoVelcro chips' high sensitivity, we found that patients responding to the given therapies have a significant negative change in their CTC numbers.
Similar(47)
In patients with hemiplegia, significant (positive) CBV changes were observed in ergometer, facilitation, stand-up, and gait and significant (negative) changes with Romover.
The most significant negative changes for developing countries in Asia, where agricultural production declines of about −4% to −10% are anticipated under different socioeconomic and climate change scenarios.
Yet surprisingly, surveys have shown that Russians have a difficult time describing any significant negative changes in their lives that have been caused by immigrants.
In addition emotional well being (p = 0.03) and health distress (p = 0.03) showed significant negative changes.
The Affect, Cognitive Competence and Difficulty scores showed significant negative changes, while the change on the Value score was non-significant.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com