Data were analyzed using SAS 9.2 (SAS Institute, Cary, NC), and P < 0.05 was considered nominally statistically significant without multiplicity adjustment.
Although not statistically significant, the tumor multiplicity of SCC I in K5-VILIP-1 mice was lower than in WT mice (0.68 SSCI/mouse versus 0.88 SCCI/mouse).
In addition, testing for interactions is power-intensive (Hunter 2005), and testing a large number would impose a significant power and multiplicity burden (Thomas 2010).
Mean change from baseline in SDS total score was not significantly different for either dose of vilazodone versus placebo when adjusted for multiplicity; significant improvement versus placebo was noted for vilazodone 40 mg/day without adjustment for multiplicity (P =.0349).
If either PCS and/or MCS scores of SF-36 were statistically significant, significance was tested for the individual domain scores, without P value corrections for multiplicity.
Results remained significant after accounting for multiplicity.
# p-value significant (when adjusted for multiplicity), Chi squared test.
There was a significant association between HPV multiplicity and the prevalence of HIV.
Of the main effects radiation associated QTLs investigated in this paper, Mrip2 and Mrip3 showed the most significant association with tumour multiplicity followed by Mrip1, Mrip4 and Mrip5.
Among results from the minimum p-value test, CASP1/5/4/12, CASP14, and IGFBP3 were the most promising gene regions, but were not significant after adjustment for multiplicity (total number of SNPs) over the entire gene (Table 1).
