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'significant mortality' is correct and usable in written English.
You can use it to refer to a large number of deaths or an increased risk of death. For example, "The study showed a significant mortality rate among individuals with the disease."
Exact(60)
However, it is highly pathogenic for domestic poultry, causing significant mortality in chickens and turkeys.
Necrotising enterocolitis (NEC) causes significant mortality in premature infants.
Cardiovascular disease (CVD) accounts for a significant mortality rate worldwide.
Significant mortality and morbidity are associated with pelvic insufficiency fractures.
Despite remarkable efforts, metastatic melanoma still presents with significant mortality.
These disabling injuries are associated with significant mortality, loss of independence and financial burden.
Aides to the bill's sponsors said they were unaware that the measure had overlooked these other significant mortality factors.
The development of acute kidney injury (AKI) after cardiac surgery is associated with significant mortality, morbidity, and cost.
"The Formby red squirrel population will become infected by squirrelpox again and it will cause significant mortality but hopefully it won't be as high as 85% next time".
The CQC inspected the unit over two days in December because it "had been identified as a significant mortality outlier when compared to similar services".
Their deadly venoms cause significant mortality and morbidity worldwide, and strike fear in most of us.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com