Sentence examples for significant limitations with from inspiring English sources

The conventional heart-valve prostheses have significant limitations with either life-long anticoagulation therapeutic associated bleeding complications (mechanical valves) or limited durability (biological valves).

"Drag-and-drop type development software has significant limitations with regards to the form and function of the app you're making.

However, the currently existing MPSoC architectures have significant limitations with respect to safety critical applications.

Despite the advancements in technology current valve substitutes continue to have significant limitations with regards to thrombogenicity, durability, and inability to grow or remodel.

As I will describe shortly, this mediated experience -- a screen is always between them and life -- has significant limitations with real implications on their development.

Despite this progress, HIS mice have significant limitations with respect to longevity of engraftment, production of myeloid cell populations, and the consistency of immune cell function in experimental replicates within a group[10].

The most significant limitation with 'risk-centric' approaches is that fundamentally, the activity may be defined as pathological and unhealthy.

A significant limitation with use of the currently available data should be recognized.

This represents a significant limitation with respect to realizing the public health benefits of SMS.

This may be a particularly significant limitation with respect to prescription opioid use, which has been rising rapidly nationwide [ 9- 11].

A significant limitation with these two studies is the differences in gross structure that may explain the observed relationships with pain.