Sentence examples for significant limitations for from inspiring English sources
The inability to mimic the complexity of the liver using cell lines and regular primary human hepatocyte (PHH) cultures pose significant limitations for studying host/pathogen interactions.
The formidable barrier properties of the uppermost layer of the skin, the stratum corneum, impose significant limitations for successful systemic delivery of broad range of therapeutic molecules particularly macromolecules and genetic material.
Our results suggest that while some differentially expressed genes were identified by this method, the cross-species hybridization appears to have significant limitations for the transcriptome analysis of tall fescue.
Living nerve cells from people with the disease have not been readily available for study, and animal models remain problematic two significant limitations for researchers.
However, there is an increasing awareness that anatomical approaches based on measurements of tumour size have significant limitations for assessing therapy response [10].
Regardless of its sufficient labelling stability with DTPA, 111In is associated with photon energies that are suboptimal for in vivo imaging and long half-life resulting in relatively high radiation burden, which both represent significant limitations for the translation of this radiolabelling approach to clinical studies.
The increasing volume of scientific data and the limited scalability and performance of storage systems are currently presenting a significant limitation for the productivity of the scientific workflows running on both high-performance computing (HPC) and cloud platforms.
This could represent a significant limitation for small fire detection and precise localization.
This identifies the equimolar counterdiffusion assumption as a significant limitation for predicting performance with macro-mesoporous adsorbents.
High number (>100/year) of freeze and thaw (F&T) cycles in Poland is a significant limitation for porous asphalt technology.
Nanocarrier toxicity has been a significant limitation for traditional formulations, such as liposomal or polymeric nanocarriers.
