Sentence examples for significant life span from inspiring English sources

The compression of morbidity is of particular interest, since an increasing number of reports document amelioration of a variety of aging phenotypes without significant life span extension [ 6].

Metformin supplementation (50 mM dose) was shown to increase the mean life span, but not maximum, of C. elegans, although 10 or 100 mM doses showed no significant life span benefit [ 41].

The latest study in brain-specific Sirt1-overexpressing (BRASTO) transgenic mice demonstrated a significant life span extension of 11%, and aged BRASTO mice also exhibited a clear delay in aging phenotypes [ 7].

Using the two transgenic dSir2 lines that were reported not to extend life span, we are able to show significant life span extension when dSir2 expression is induced between 2 and 5-fold.

In this study, we demonstrate that targeted expression of exogenous UCP in adult IPCs results in attenuated systemic insulin signaling, a mild hyperglycemia and a significant life span extension.

As expected, attenuated insulin signaling measured in dilp2-Gal4/UAS- mucp1 and dilp2-Gal4/UAS- hucp2 flies is also associated with a significant life span extension in females and a moderate increase in males [ 24].

We found that adult flies with precise excision (Ex f07745) were much more sensitive to hyperoxia and had a significant shorter life span than flies with P-element insertion (Fig. 4C, p<0.01) and embryos from this precise excision line could not develop into adult flies in 90% O2 (data not shown), further demonstrating the important role of this particular gene, as an example, in oxidant stress.

grafted B16 melanoma with a significant increase in life span (161% and 272%).

In a pilot test, cancer-susceptible Trp53−/− mice fed a diet supplemented with the high-anthocyanin tomatoes showed a significant extension of life span.

In summary, knockdown of DTK or sNPF with either of the two Gal4 drivers led to a highly significant decrease in life span at desiccation.

In contrast, honokiol treated group resulted in a significant increase in life span (P<0.05, by log rank test) and 50% rats survived at 33 days (Figure 5, A).