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He won't talk about it but one friend says it was 'a significant knock to a man who has not had many significant knocks'.
I think [Obama's] proven record as a public person stands as a significant knock down to whatever youthful transgressions somebody might have had.
The most significant knock against evolutionary responses to contemporary climate change revolves around evolutionary rate.
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"There has been a significant knock-on effect," she says.
The ageing workforce had a significant knock-on effect.
Poor air quality is also having a significant knock-on effect on the country's tourist trade.
A significant knock-on effect of further ad restrictions on television will be to starve broadcasters of programme budgets.
If they recover slowly from flood events it can have a significant knock-on effect for the wider community".
As human emissions of greenhouse gases continue to rise, natural ecosystems come under extreme stress with "significant" knock-on effects for societies.
Teams that are relegated, he clarifies, can have a significant "knock-on effect for the town or city … more miserable faces would mean less productivity.
The White House has played down fears that volatility in international stock markets, particularly in China, would have any significant knock-on impact on the US economy.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com