Sentence examples for significant issue of concern from inspiring English sources

Development of new nanofabrication methods is always a significant issue of concern.

Finally, ground stability is a significant issue of concern in karst regions.

Thirdly, as children living with HIV grow into adolescents, sexual health becomes a significant issue of concern.

However, a significant issue of concern in performing any contouring algorithm is the initialization of the contour, especially for the case of liver segmentation, where other organs in close proximity have similar intensity distributions.

The commission's report found "significant issues of concern, including health and safety".

Vaccines administered in this manner will offer improved safety with respect to disease transmission and needle-stick injuries among health care workers, significant issues of concern in developing countries where the demand for many vaccines is high [55].

However, from an implementation perspective adherence and acceptability are other significant issues of concern which will determine the effectiveness of such large scale interventions.

"It's a significant issue, and I think it's a significant issue of public concern," Blair said.

Increased HIV prevalence in HR-MSM of ages 18 20 years, though not statistically significant, is still an issue of concern and requires in-depth examination.

A significant issue concerning the use of epigenetic targeting agents in conditions such as rheumatic disease is that these are chronic conditions and require long-term treatment regimens.

Thus, the controllable fabrication of the patterned GaAs substrate is a significant issue of concern.