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In our study, all three PK-PD indices (Cmax/TRE, AUC0 48/TRE, and % T>TRE) correlated well with a reduction in parasitemia as a consequence of their significant interdependency (Spearman correlation coefficient, >0.97; P value < 0.0001).
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Of the 90 possible combinations, 29 exhibit statistically significant interdependencies.
The problem will be most pronounced in large groups where significant interdependencies among group members are absent.
Given the significant interdependencies of health and socioeconomic status, the above range of indicators were necessary to provide a reasonable picture of Liberia's challenges and progress in the post-conflict period.
In a distributed computing environment, where the data is located on multiple sites, this approach creates significant data interdependency issues as data needs to be transferred from multiple sites in order to be recombined, allowing the analysis to proceed to the next step.
The disadvantage of this approach however is that it creates significant data interdependencies, which in turn lead to data transfers that can severely degrade performance and increase overall costs.
We expect substantial interdependencies for the immunological parameters in our study (Table 1).
The topic of drinking water, for example, revealed various significant feedbacks and interdependencies including climate change and close connections between the city and its hinterland that demanded close cooperation.
The description step was followed by the selection of significant resistance-altering interdependencies between the physicochemical properties of the 560 amino acids of p66.
Interviewees expressed an interest in greater internal collaboration on budgets to capture significant cross-departmental interdependencies as well as more communication throughout the process, especially in the form of inter-departmentally, where there seemed to be a lack of information sharing.
Such complexity indicates that designing the optimal solution for a specific, desired transformation, i.e. both preparation of a catalyst and the course of this transformation, will not facilitate the execution of other tasks, even closely related ones, because of the multitude of significant factors and the multitude of interdependencies.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com