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In vivo experiments showed that chidamide combining cDDP exerted significant inhibitory effects on ACC.
Fluoxetine produced some dose-dependent and significant inhibitory effects on all the signs of ethanol withdrawal during ethanol withdrawal period.
All three drugs had some significant inhibitory effects on EWS-induced behavioral signs beginning at the 2nd hour of withdrawal.
It can be concluded that Bortezomib has significant inhibitory effects on the growth of HGC-27 cells.
As a result, allocyathin B2 (11) was observed to exhibit significant inhibitory effects on NO production with an IC50 value of 19.8 μM (natural product quercetin: IC50 = 4.3 μM), whereas the remaining compounds had no effect.
Hence, the significant inhibitory effects on both of these inflammatory mediators unravel a novel anti-inflammatory action of this plant.
However, complex 4 exhibits significant inhibitory effects on the Topo I activity at a very low concentration ∼2.5 μM.
Importantly, significant inhibitory effects on the viability of the MG-63 osteocarcinoma cancer cells at 12.19 μg/mL of IMT-MBG were observed.
Olanzapine (2 mg/kg) produced significant inhibitory effects on stereotyped behaviors and wet dog shakes at the 6th h of ethanol withdrawal.
It showed significant inhibitory effects on the production of inflammatory cytokines including TNF-α, IFN-γ, IL-6, and MCP-1.
Only hydroxytyrosol (but not tyrosol) had significant inhibitory effects on endothelial cell proliferation, migration and "tubule-like" structure formation on Matrigel.
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