Most of all, we need business leaders prepared to stake their significant ingenuity, imagination, resources and capital on long-term value creation.
Most buyers were of modest means but significant ingenuity, so there was a period of experimentation in power sources, from windmills to simple generators to modified automotive parts.
These were difficult, sometimes dangerous undertakings – and they took significant ingenuity by health workers to chase the virus.
An FDR cutoff of 0.1 and a P value cutoff of 0.05 were considered significant IPA (Ingenuity Systems, Redwood City, CA, USA), with KEGG pathways used to generate gene networks and functions in HCC tumorigenesis and development.
Literature scholar Mimi Reisel Gladstein described the play as "significant for dramatic ingenuity and thematic content".
Pathway analysis of these 58 proteins identified four significant networks using Ingenuity (Figure 2 and Figure S1) and five networks with MetaCore's workflow (Figure S2).
Pathway analysis of the 48 proteins that were found to be upregulated in mouse plasma with tumor development, but not identified as secreted or surface membrane proteins in ovarian cancer cells yielded three significant networks with Ingenuity (Figure S4, Table S5).
Subsequently, we performed a gene pathway analysis of significant genes with the Ingenuity Pathways Analysis (IPA) software, version 6.0 (Ingenuity Systems, Mountain View, CA).
Significant functions were calculated by Ingenuity Pathways Analysis (Ingenuity Systems, Redwood, CA, USA) with DAVID software (National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA; available from http://david.abcc.ncifcrf.gov/) from a list of genes showed a 1.5-fold increase or decrease following treatment with AUY922.
We further analysed the significant genes for resistance by the Ingenuity Pathways Analysis (Ingenuity Systems, Mountain View, CA, USA; http://www.ingenuity.com).com
"This was the product of creative, human ingenuity, resulting in significant new applications for human health that were previously unavailable," it said.
