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'significant increased' is correct and usable in written English.
You would use this phrase when referring to a large or notable increase in something. Example: The company saw a significant increased in sales last year.
Exact(55)
However, high consumption of red meat in the shorter term was associated with a significant increased risk of cancer of the rectum.
There is a significant increased risk of injury from overuse, excessive repetition of the same action.
The results revealed a highly significant increased (P < 0.01) in the malondialdehyde (MDA).
The interactions between these variables contributed to significant increased xylanase production.
Significant increased level was detected in YTE variant group as compared with WT huE6F6 group (Fig. 1B, P < 0.05).
But not every driving error in those situations results in significant increased fuel consumption or component wear.
Similar(5)
Light to moderate drinking is associated with small and non-significant increased risk of overall cancer.
Storing pesticides in the house was associated with a statistically non-significant increased risk.
High dose exposure to indoor tanning showed a non-significant increased risk for basal cell carcinoma.
IV drug use was associated with a large, but non-significant increased risk of missed presentation.
Most case control and cohort studies showed a non-significant increased risk.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com