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"significant improvement over" is correct and usable in written English.
You can use it to describe a significant increase in something compared to what it was before. For example, "We saw a significant improvement over the last quarter, with our profits almost doubling from the previous year."
Exact(53)
Significance: Flow cytometry is a significant improvement over fine-needle aspiration derived cytologic diagnosis alone.
The "Lost" deal represents, for the writers, a significant improvement over similar situations elsewhere.
Only the higher dose represented a statistically significant improvement over the placebo.
There was also significant improvement over time in the control group.
In this regard, plastics produced from BioAmber's succinic acid don't represent a significant improvement over conventional ones.
And I think both of them would be a significant improvement over where the country is right now".
The company's short-term business conditions are difficult, he added, but he foresees significant improvement over the next three years.
It's a significant improvement over the previous software.
This results in a significant improvement over using image pyramids.
Similar(2)
The variety in this latest round shows significant improvement over last year.
He would find seven fairways, a significant improvement over the first round, when he hit three.
More suggestions(15)
remarkable improvement over
huge improvement over
notable improvement over
significant advancement over
large improvement over
noteworthy improvement over
salient improvement over
significant enhancement over
significant development over
considerable improvement over
tremendous improvement over
substantial improvement over
sizable improvement over
significant achievements over
significant developments over
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com