Mr Downer said Douglas Wood, a 63-year-old engineer, had significant heart problems.
However, bradycardia may indicate significant heart disease if accompanied by other symptoms.
Dr. Aponte performed autopsies but found nothing to explain the deaths: no trauma, no drug overdose, no significant heart or internal-organ abnormalities.
To put this into some perspective, in someone that has had a significant heart attack, the levels would be somewhere 20 to 50 times higher.
In 2001, I was part of a team from the Cleveland Clinic that published a paper demonstrating the significant heart attack risk of Vioxx.
At Lawnwood, where an invasive diagnostic test known as a cardiac catheterization is performed, about half the procedures, or 1,200, were determined to have been done on patients without significant heart disease, according to a confidential 2010 review.
In another incident, an outside expert described how a woman with no significant heart disease went into cardiac arrest after a vessel was cut when a Bayonet Point cardiologist inserted a stent, a meshlike device that opens coronary arteries.
In a written statement, the commissioner, Andrew C. von Eschenbach, said the agency has asked the makers of Actos and Avandia to carry the more prominent warning, a so-called black box warning, of its heart risks because "despite existing warnings, these drugs were being prescribed to patients with significant heart failure".
Yet in brave defeat they can take significant heart.
In unanesthetized rats, l-glutamate caused significant depressor responses without significant heart rate (HR) effects.
Ultrasound demonstrated dilated IVC and hepatic veins as well as significant heart enlargement with reduced systolic function.
