Sentence examples for significant functional role from inspiring English sources

Gene disruption may also play a significant functional role when known gain-of-function oncogenes are amplified.

Even though MIRO2 initially appeared to be dispensable in gametophyte function, ovule development and embryo development compared to MIRO1, it has retained a significant functional role.

With the full length LfcinB however, the native disulfide bond that connects the ends of the peptide does not have a significant functional role, as seen by the similar activities between the oxidized and reduced forms of the peptide.

However, as the protein sequence in this region is conserved in all chordopoxviruses with only minor amino acid differences (seen primarily in the avipoxviruses and molluscum contagiosum virus), it may play a significant functional role.

Our further functional results indicated that perturbations in stathmin phosphorylation play a significant functional role in mediating apoptosis in MM cells exposed to bortezomib and the bortezomib-induced changes in the MT stabilization can be attributed to the bortezomib-induced phosphorylation of stathmin.

It is noteworthy that rs3212227, which was replicated in the African-American cohort lies in an evolutionarily conserved region (analyses not shown; Vista Browser 2.0, http://genome.lbl.gov/vista/index.shtml), reinforcing the idea that the 3' end of gene might play a significant functional role in vivo [32].

In addition to those already discussed, several miRNAs within this set have significant functional roles in other mammals, some with potential significance to bat biology.

Some of these nc-RNAs might have important predictive values and significant functional roles in breast carcinogenesis.

It is not known if any of these mini-IS elements have significant functional roles, e.g., through effects on expression of other chromosomal genes.

These results demonstrate that these four ECM proteins play significant functional roles in the metastatic dissemination of these mammary tumor cells.

To establish whether the 839 term DMPs linked to Ref Seq-annotated genes had significant functional roles, we used GO pathway analysis.