Sentence examples for significant functional implications from inspiring English sources

In this study, we detected misfolded tau in a significant fraction of presynaptic and postsynaptic terminals in AD subjects, which had two significant functional implications: (1) it could impair brain network function; (2) it could represent the anatomical substrate of tau synaptic transmission.

The conformational flexibility of the N-HEAT region may provide significant functional implications, for example, adopting different conformations for the interactions with various mTOR regulators (Kim et al., 2008; Wullschleger et al., 2006; Zoncu et al., 2011).

The role of HGT in eukaryotic evolution was generally regarded as more limited if one excludes their ancestral organelle endosymbioses, but is now gaining greater attention with the increasing number of well supported cases, many of which with significant functional implications [4].

Indeed, a shift from CB1R to CB1R CB2R signaling could have significant functional implications.

Hence, we think that one of the biggest challenges of comparative genomics lies in the identification of changes in genome content that had significant functional implications.

The referees agreed that the study is of high quality, and that the results are important because they establish the presence of nucleo-cortico feedback, which is likely to have significant functional implications for certain regions of the cerebellar cortex.

This may have important functional implications.

The ranking of the groups in terms of overall memory impairment (AD < LLS < DEP) and the large effect sizes observed when patients with LLS were compared with those with DEP and AD has <span class="lh">significant therapeutic and functional implications: interventions to enhance cognition in LLS should have a special focus on memory.

Beyond abundance, the spatial organization of immune cells in relation to cancer cells may also have significant functional and clinical implications.

The objective of this study is to determine whether adults with BSCP have greater adiposity in and around their skeletal muscles than their typically developing (TD) peers as this may have significant functional and cardio-metabolic implications for this patient group.

Given the very small p-values, there is every reason to suspect that certain unraveled functional implications of the LOAD underlay these significant enrichments.