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Genu recurvatum occurs in 4 16% after hamstring lengthening but seldom has a significant functional effect as it does not usually exceed 5 10° and also improves with time [9, 11, 16, 24].
However, a rare promoter variant, which exerts a significant functional effect on the ghrelin receptor transcription, showed partial co-segregation with obesity and overweight when examined in 2 pedigrees of whites.
When GIRK signalling was eliminated either with tertiapin or gene-knockout, a significant functional effect of MOR agonists remained (Mitrovic et al., 2003; Marker et al., 2004; Nakamura et al., 2013).
> -wrap-foot> Although interindividual differences of action frequency had been controlled, no significant functional effect of group × condition interaction was found after implicit masking with the effect of monitoring.
We determined that [100 ng/ml] was the lowest concentration at which VEGF-C had a significant functional effect on L-LECs (data not shown); therefore, we conducted our studies at this final concentration.
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Previous studies have too been able to pick up significant functional effects in similar small sample sizes [42].
APS and HPS haplotypes produce significant functional effects, coding for 3- and 20-fold reductions in COMT enzymatic activity, respectively.
The γ3R225W mutation has significant functional effects as demonstrated by increases in basal and AMP-activated AMPK activities, increased muscle glycogen and decreased IMTG.
The data shows that strain-specific antibodies, despite being present as determined by competition ELISA, did not have any significant functional effects on parasites in vitro.
As more detailed information about the genome becomes available, many of the poorly understood regulatory elements (SNPs in introns, 5' and 3'UTRs) may be shown to exert more significant functional effects.
Although Mg++-induced depolarization could, at face value, increase cell excitability, the surface charge screening effects described above would prevent significant functional effects of the depolarization on excitability.
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