Sentence examples for significant functional changes from inspiring English sources

The finding that patients reported clinically significant functional changes through 2 years is important to highlight.

Pain progression has been evaluated in MOH patients, suggesting the presence of a global alteration in the processing of noxious stimuli throughout the pain matrix and the occurrence of significant functional changes in the lateral pain pathway [28].

Polymorphisms that might cause significant functional changes, such as nonsynonymous or insertion/deletion polymorphisms, were not found in the polymorphism screening of the human KCNJ6 gene in the present study, possibly attributable to the importance and high conservation of mammalian GIRK channels.

7 During this time, hyperglycaemia develops insidiously and causes significant functional changes to various target tissues.

Such modifications are believed to impart significant functional changes to the miRNA.

There were no significant functional changes in any patients and no neuropathic pain.

The numerical level that would be considered good, or what change in soil organic matter levels constitutes a significant functional change, has not been established [28].

Basic usage is as follows: The most significant functional change here is that the SMILES parser automatically locates the positions of double bonds in de-localised aromatic systems (Kekulisation).

Firstly, drug resistance, by necessity, requires a significant functional change in the parasite, and hence a functional change in one or more proteins.

We find that computational tools are very successful in diagnosing laboratory-induced mutations that elicit significant functional change in the laboratory (up to 92% accuracy).

Based on these results, a local difference in implicit time must be greater than approximately 1 Z-score unit to differentiate it from inter-instrument variability and establish a significant functional change at a single retinal location.