For seminal vesicle only two functions reached significance and for salivary gland no significant function was found.
In Table 1, in total, 10 functions were enriched; the most significant function was that of intracellular transport (P=3.21E-16).
For the total list, see Additional file 4. Another statistically significant function was formation of cellular protrusions and plasma membrane projections.
At all time points, the largest GO-function categories being enriched are those comprising 'cellular and metabolic processes', while the most significant function being enriched is the 'response to stimulus' (Additional file 5).
The most significant function was cholesterol efflux, with p-values of 2.33E-09, 2.41E-11 in the PFO closure and no-closure data sets, respectively and z-scores of 2.73 and 2.37 in the PFO closure and no-closure data sets, respectively.
The grouping variable effects of two significant functions are described and implications for career counseling and future research are discussed.
In both types of analyses, statistically significant functions were determined using the Fisher Exact test.
The first most significant functions were nervous system development and function (p-value = 1.6E-05 1.6E-05-02), followed by organ development (p-value = 1.6E-05 – 2.72E-02) and infollowedmechanism (3.13E-04).
Regarding the DE genes that were down-regulated in tumors of T1-Grade III and were simultaneously up-regulated in tumors of T2/T3-Grade III, genes were identified whose significant functions were cell-cell communication and signal transduction (Figure 10J).
Four significant functions were associated with these networks: lipid metabolism (11 proteins, p = 6.98×10−8), small molecule biochemistry (16 proteins, p = 6.98×10−8), molecular transport (14 proteins, p = 1.2×10−7), and protein synthesis (7 proteins, p = 1.68×10−7).
The most significant functions were cancer, cellular growth and proliferation and hematologic system function and development.
