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"significant fluctuations" is a correct and usable phrase in written English.
You can use it when discussing a noticeable change in something, usually over a period of time. For example, "The stock market experienced significant fluctuations over the past week."
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Their prices may be susceptible to significant fluctuations due to speculative activities.
As can be seen, there were no significant fluctuations.
Variable accounts are "more likely to have significant fluctuations in usage…from period to period," according to the company.
For separations larger than ~40 degrees, the signal remains negative without any significant fluctuations.
Our findings suggest significant fluctuations in adolescent mood and everyday hassles across school-vacation cycles.
Barren ground caribou (Rangifer tarandus groenlandicus) herds experience significant fluctuations in abundance through time.
Intermittent operation of the SEHRAC can lead to significant fluctuations in operating conditions.
In addition, some researchers observed significant fluctuations of their contact angle data.
Nevertheless, under realistic channel conditions, no significant fluctuations from the assumed optimum performance under the flat channel assumption was observed.
Hence, a pre-determination of prediction modes will reduce the coding complexity without significant fluctuations in the rendered view quality.
As shown in Fig. 6, the majority of intracellular metabolites had undergone significant fluctuations under different initial glucose concentrations.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com