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"significant failure" is correct and usable in written English.
You can use it when discussing a failure that is noteworthy or meaningful, such as one that has far-reaching or long-term consequences. For example: "The company's significant failure to make a profit in the previous quarter caused considerable anxiety among investors."
Exact(58)
"It was a very significant failure in reporting," Mr. Portsche said in a recent interview.
My advice, humbly offered, would be as follows: First, you need a significant failure.
"There is a significant failure of communications regarding the environment," Edelman wrote.
In 1965, there came the first significant failure of his career and it was one that rankled.
It is considered a significant failure for the Labor Party government of Tony Blair, which promoted and subsidized the Dome.
So we are obviously taking it very seriously, because it is a significant failure".
If I was doing my list of tick-boxes, rather than just GCSE goals, I would say, 'Significant failure; disaster.'" So does he actually advise Gove?
Laurence Williams, the chief nuclear inspector, said, "If we see any signs of significant failure to deliver, we will not hesitate to use our extensive enforcement powers".
The review was carried out by Mark Ellison QC and reported last March, adding that there had been "a significant failure in the disclosure made by the MPS".
But the term can have a variety of implications, and does not necessarily mean that any of the bridges are in real danger of significant failure.
Apple is facing its first significant failure in years with anger over the mapping service introduced this week for iPhone users.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com