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A1C differences between the groups would likely be sufficient to permit evaluation of clinically significant end points such as retinopathy and microalbuminuria, as well as β-cell function.
The study was not adequately powered to determine more clinically significant end points such as rate of dialysis requirement, hospital or ICU length of stay, differences based on etiology of renal dysfunction, or mortality.
The results of several earlier meta-analyses conducted in general ART populations indicate that supplementation with r-hLH offers no benefit in terms of clinically significant end points in IVF/ICSI cycles, including the number of oocytes retrieved, the number of mature oocytes and the rates of implantation, pregnancy, miscarriage and/or live births.
To fully generalize these results, additional studies would be required, which include a large sample of males, African Americans, longer treatment and follow-up phases, additional data on prior CC history and risk factors, assessment of clinically significant end points, such as frequency of bowel movements, and ease of evacuation.
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The forest plot presents the most significant end point from the meta-analysis of stages 1 and 2 for all SNPs except rs12302097.
When the MDD model relies on the application of stress to provoke depressive-like behaviours, the measure of peripheral stress hormones is often added as a significant end point to evaluate antidepressant activity.
Overall, therefore, no data from adequately powered multicenter trials with clinically significant end-points and adequate safety are available to recommend fenoldopam to either prevent or treat AKI.
Inert ingredients can increase the ability of pesticide formulations to affect significant toxicologic end points, including developmental neurotoxicity, genotoxicity, and disruption of hormone function.
Michael DeVito, acting chief of the NTP Laboratory, says DO mice could help toxicologists ensure that they don't miss a potentially significant human end point.
12 Similar to Willett et al., Hew et al. did not observe an association between ≥80% pathologic tumor necrosis and distant recurrence-free survival, suggesting that this threshold may not be a biologically significant surrogate end point.
If the sample size is big enough, maybe gender difference will become statistical significant for more end points.
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