Scintillation presents a challenge for the receiver in an OW link, since the receiver must have significant dynamic range, which may need to be more than 40 dB, to handle large variations in the received intensity.
mRNA and protein turnover rates as well as mRNA translation rates exhibit a significant dynamic range.
Two of the potentially 12 orders of magnitude are plausibly overcome by the judicious use of immunoaffinity columns although there still remains a significant dynamic range to overcome.
Moreover, using diffraction theory to determine the drop-off in the axial response, this configuration was shown to achieve a significant improvement in dynamic range compared to that of a comparable single axis design [ 13].
While underlying physiological differences contribute to the variability observed, the ability to detect statistically significant differences in dynamic range derived from parameter changes in relatively small patient groups would appear to support these hypotheses.
Recently, digital PCR (dPCR) has gained increasing popularity [ 10] due to its upgrading to the so-called "droplet digital PCR" (ddPCR) systems which, compared to other platforms of dPCR, enable a significant gain in dynamic range while decreasing the cost of analysis [ 10, 11].
However, the identification of proteins expressed in a given sample has presented unique analytical challenges, including significant molecular diversity, dynamic range of proteins at the cellular level, extreme complexity of post-translational modifications and a tendency to adsorb to solid surfaces [ 23].
Indeed, in many designs, the truncation method is still widely employed and quantization errors play a significant role in the dynamic range of filter gain and increase with filter order [11, 12].
Compared to microarrays, the emerging RNA-Seq provides digital gene expression measurements that offer significant advantages in resolution, dynamic range, and reproducibility.
Proteome pre-fractionation in gel (geLC-MS) has resulted in a significant proteome depth and dynamic range in studies were > 5000 distinct proteins were confidently identified and quantified.
Light harvesting can be applied to established sensing schemes and materials without a significant influence on the dynamic range, selectivity, and sensitivity.
