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The term 'significant drawbacks' is correct and usable in written English.
You can use it to describe any negative consequences of a situation. For example, "The new policy had some significant drawbacks; it led to a decrease in employee morale and productivity."
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Taking a principled drive, though, comes with significant drawbacks.
But other leading contenders have significant drawbacks of their own.
What significant drawbacks are there to your plans?
Part II: What significant drawbacks are there to your plans?
But such a move has several significant drawbacks.
However, the type of approach taken by these studies suffers from some significant drawbacks.
Doctors and patients have been looking for an alternative to warfarin because of its significant drawbacks.
The funds can also have other significant drawbacks, several industry analysts said.
But what may appear to outsiders as a life of luxury -- or lethargy -- can have significant drawbacks.
However, the dirty bomb does have significant drawbacks as a weapon.
But systems that rely solely on a connected phone have significant drawbacks.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com