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"significant drain" is a grammatically correct and commonly used phrase in written English.
It can be used to describe a situation where a large amount of something is steadily being reduced or depleted. Example: The construction of the new highway has caused a significant drain on the city's budget.
Exact(31)
But farming can also be a significant drain.
Using the camera can be a significant drain on the battery, especially video recording.
But although it is now self-funding, such programs are a significant drain on Bard's resources.
Such outflows are already a significant drain on the balance of payments.
"The result would be a significant drain on the state's fisc —— one it can ill afford at present," he added.
However, costs involved also means that ill-fated retail investments can be a significant drain on finances and management resources.
Similar(27)
But Mr. Bernanke suggested that "if economic and financial developments were to require a more rapid exit from the current highly accommodative policy" that is, if fears emerge about inflation the Fed "could increase the interest rate paid on reserves at about the same time it commences significant draining operations".
The marshes and meres surrounding the village supported fishing since Saxon times, at least until significant draining during the 17th century.
In developing countries, the cost of health care financing is one of the biggest social challenges and out-of-pocket payments present significant drains on household spending patterns, making health insurance one of the best social interventions [ 1].
Finally, losing the EMA could lead to a significant brain drain.
So we import skilled labour from other countries, which can in turn lead to a significant brain drain elsewhere.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com