Yet this approach has significant disadvantages.
This support helped Mr. Thompson overcome some significant disadvantages.
But to me it has two significant disadvantages.
And they hold at least two significant disadvantages for Bristol and Sanofi.
The uranium that makes conventional nuclear power possible has a number of significant disadvantages.
FLAC captures all the information in the recording, but it has two significant disadvantages: it produces large files, and not all portable music players can handle it.
Such an offering might be a hard sell to investors, and there could be significant disadvantages for the firm as well.
The installations were expensive and difficult to scale, he said, significant disadvantages in the rapidly expanding peer-to-peer market.
The group weighed several other candidates, but saw each as having significant disadvantages or lacking sufficient stature.
New Jersey has significant disadvantages for cheap energy production: it has no large dams to provide hydroelectric power; there are no big coal deposits; the state has a dense population with a constant demand for electric power.
There were significant disadvantages to acquiring my two undergraduate degrees – six years of constant hard work entailing virtual obsession with the course for most of the year is bound to affect domestic relationships.
