Sentence examples for significant difficulty to from inspiring English sources

There is no significant difficulty to use the coarse aggregate by using not only the natural coarse aggregate but also the crushed aggregate.

The ~400 and 120 kDa bands were similarly active towards albumin and goat IgG at all the pH values tested, except for the case of goat IgG where these two bands displayed higher activity at pH 9. Of note, bands of 400 and 120 kDa displayed a significant difficulty to be separated in gels copolymerized with these two substrates.

Nottingham potential bursaries of £1,000 are also offered to students from lower income backgrounds and/or those who have overcome significant difficulties to come to university.

This does not deny that there are significant differences between the vanishing spray and, for example, goal-line technology or instant replay, and that there are equally significant difficulties to evaluate and implement technological innovation in refereeing.

Incredible Years is a parenting skills training program for families with children between 4 to 8 years with behavior problems whose parents have significant difficulties to manage.

This adds significant difficulties to conduct group-level analysis (such as statistical parametric mapping, SPM [8]) and poses technical challenges to perform atlas-based anatomical labeling and ROI analysis [9, 10] with minimal or no human intervention.

This myriad of selective pressures creates significant difficulties to the identification of codon-context biases associated to mRNA translation only.

In addition, multiple medications and multiple daily administrations may be a necessary inconvenience and, for a subset of patients with dexterity problems, present significant difficulties to its use.

Collectively, these results suggest a shared molecular basis among fragile sites, indicating that the DNA sequences within these regions can present significant difficulties to the replication machinery, and require the activation of DNA damage checkpoint proteins.

Exclusion criteria were: age <18 years, diabetes diagnosed before pregnancy, medications that influence glucose metabolism (e.g. oral corticosteroids and metformin), multiple pregnancies, physical disability, current substance abuse, severe psychiatric disorders and significant difficulties to co-operate (e.g. inadequate Finnish language skills).

If home prices decline 20% over the next several years, a reasonable scenario, then American households will see a $4.2 trillion loss in their net worth and have significant difficulty adjusting to this decline.