Sentence examples for significant difficulty is from inspiring English sources

A significant difficulty is that one cannot be sure that the sonnets are autobiographical.

The most significant difficulty is the inability of these in vitro 3D models to fully mimic the defined in vivo 3D orientation, of either normal (i.e. polarity; distinct structural architecture) or aberrant (loss of structural integrity) epithelial cells, that dictates intracellular, intercellular and cell extracellular matrix (ECM) signaling [ 33].

Being wireless without significant difficulty was a revelation.

On the contrary, no significant difficulties were observed with the prototype of FB.

No significant difficulties were encountered when translating it from English to Italian, except for one question where the fact that the level of competition in the original text is described in relation to the American league system required adaptation to Italian professional sport categories.

So far they have yielded no accusations of systematic abuses and one or two significant arrests.The difficulty is what comes next.

The ANOVA of the area under the curve shows that the interaction between Subtraction Difficulty and Text Entry Difficulty is significant in combination with the listening task, but not without it (see Table 4).

Among the three factors, the effect of DWD on item difficulty is statistically significant at a level of.05.

A diagnosis of a specific reading difficulty is a significant concern for parents and children and it is possible that basic binocular visual problems are overlooked amidst the investigations.

The ~400 and 120 kDa bands were similarly active towards albumin and goat IgG at all the pH values tested, except for the case of goat IgG where these two bands displayed higher activity at pH 9. Of note, bands of 400 and 120 kDa displayed a significant difficulty to be separated in gels copolymerized with these two substrates.

A council report said "significant difficulties" had been encountered during the work but it was still due to be completed by mid-July.