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The phrase "significant difference in" is grammatically correct and commonly used in written English.
It is typically used to describe a notable or noteworthy contrast or variation between two things. Example: There was a significant difference in opinion among the group members regarding the best solution for the problem.
Exact(58)
There is significant difference, in expression of different genes.
Ripken has made a significant difference in major league baseball.
It can make a significant difference in some races".
After one year, there was no significant difference in the condition of the two groups.
There should not be any significant difference in the nature of the debate here.
Mayor Street has encouraged faith-based and community organizations to make a significant difference in Philadelphia.
Chan praised the Cuban response, which she said, would make a significant difference in Sierra Leone.
The $25,000 we would pay would make a significant difference in their lives.
There was no significant difference in memory and short-term learning.
Which points to one significant difference: in 2012/13, the chairman is still there.
This is a significant difference in approach and there has been no consultation".
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com