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The phrase "significant determinant of" is correct and usable in written English.
It can be used when discussing factors that have a considerable influence on a particular outcome or result. Example: "Education is a significant determinant of an individual's career success."
Exact(60)
The only significant determinant of performance was the viewing eccentricity.
* Class is a more significant determinant of online production than age, gender or race.
At Radcliffe, Aldosari is researching gender dynamics, a significant determinant of health in Saudi Arabia.
Final margin status was the most significant determinant of local recurrence rates in univariate analysis.
Other research indicates that health insurance status, which can relate directly to income, may not be a significant determinant of longevity.
We also establish that the economy is a significant determinant of vote choice.
Prior experience with social media was also a significant determinant of news sharing intention.
Our findings indicate that culture is a significant determinant of cross-sectional differences in compensation structures.
Approach angle is the most significant determinant of crashes, with a critical traversing angle of 30°.
Glycemic control might be a significant determinant of GHF in these patients.
Results indicate that land quality fragmentation is a significant determinant of forest fragmentation.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com