In the nematode, mutations of the boule homologue daz-1 completely abolishes fertility in hermaphrodites due to arrest at meiotic prophase in oogenesis, while daz-1-defective males exhibit no significant defect and are fully fertile [13], [22], [23].
These flies also displayed defective STM following conditioning at restrictive 33°C with arabinose, while no significant defect was evident at permissive 23°C.
But this encouraging news also masks a significant defect.
Liesl Schillinger misses the most significant defect of Brian C. Anderson's "South Park Conservatives: The Revolt Against Liberal Media Bias" (June 26).
Because PI3K knock-out strains reveal slow growth in the axenic medium9,26, indel mutations without significant defect were enriched during cell growth in the medium.
These cells showed a significant defect in DNA ligation, which was rescued by addition of recombinant FUS or by correcting the genomic FUS mutations.
Importantly, a marked decrease in the capacity of AMA1 to co-immunopurify RON2 was observed in the RON2IL/AA compared with RON2WT (Fig. 3c) that correlated with a significant defect in invasion (Fig. 3d).
It can be concluded that the geometric configuration of a pile and the possible significant defect can be characterized with this nondestructive test.
Palpation of the corpora revealed no significant defect.
In Slit1 −/− or Slit2 −/− single mutant, no significant defect at the optic chiasm is found.
Another mutant, tyra-2, also showed a significant defect compared with wild-type worms (Fig. 1C).
