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That translates to a difference of 31.2%, which led to a p-value of 0.04, just below the arbitrary but widely used statistically significant cutoff of 0.05.
Under neutrality, the top 1% SNPs are called tSNPs, and the significant cutoff value for the ratio of tSNPs in each region was determined, given a type I error rate of 0.5%.
The significant cutoff value was defined as 0.05 divided by the number of markers.
A significant cutoff value is determined using neutral simulation (see Materials and Methods).
Conversely, no significant cutoff of Cho/Cr was found for the response variable.
We considered moderate to severe pain (NRS⩾4 out of 10) as a clinically significant cutoff.
Similar(35)
Significant cutoffs were only found for the MMP-2 levels by BIA and ELISA.
33 Owing to the limited size of our cohort, we often used less significant cutoffs for measures corrected for multiple testing, at risk of selecting less reliable signals.
Therefore, for 5 of the 8 GSC loci we analyzed, two different datasets (using two different methods for determining the significant cutoffs) suggest that their frequency spectra do not match the neutral model in D. melanogaster.
Statistically significant height cutoff was determined as the lowest value not surpassing a false discovery rate of 0.01.
We performed comparative marker selection analysis [37] to identify miRNAs that displayed statistically significant changes (cutoff of FDR<0.25) in expression during trophectodermal differentiation of ESCs.
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