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By using an algorithm that detects metabolic modules based on biologically significant changes in gene expression [33], the 'reporter metabolites', i.e. the metabolites around which significant coordinated gene expression occurs, were identified.
The latter two use significant changes in metabolite levels to identify reporter reactions around which the most significant coordinated metabolite changes occur.
We noted significant, coordinated coexpression of multiple target genes, as well as coordinated promoter demethylation, in a large set of individual tumors that was associated with the SCC subtype of NSCLC.
But significant, coordinated aid activity is going on inside the city this winter.
There has not been any significant coordinated attempt to optimize BSs energy performance in the past.
However, with rotation through the patterns in Fig. 2b, d, receiving a significant coordinated signal from three BSs is more common.
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Beneath its gossamer skin of celebrity sightings and innuendo, Page Six occupies a significant coordinate in the business cosmology of New York City.
[Page C1.] Gossip-Wielding Page Six Is a Powerful Influence Beneath its gossamer skin of celebrity sightings and innuendo, The New York Post's Page Six column occupies a significant coordinate in the business cosmology of New York City.
This approach is simple in its algorithm but powerful in resolving situations when two datasets have significant coordinate discrepancies.
Then, we extracted the mean time course from the seed regions (using a 6-mm spherical region of interest (ROI) centred at the peak significant coordinate), and Pearson correlation was used to correlate these time courses with whole-brain voxels.
NRG1 α and NRG1 β showed significant coordinate expression.
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