Sentence examples for significant constraints in from inspiring English sources
Experts in the period say that Mr. Labbé, for instance, does not take into account the significant constraints in 17th-century literary genres, which induced playwrights to use similar registers of vocabulary and greatly bridled lexical creativity.
Although this may be partly due to limitations in extrapolating pre-clinical data to patients, it may also be that there are significant constraints in the current clinical trials model that make it difficult to demonstrate efficacy.
However, a detailed analysis reveals significant constraints in the sequence and amino acid composition of the third complementarity region of the H chain (CDR-H3), which lies at the center of the antigen binding site.
In other words, one of the most significant constraints in the re-designing of a closer-to-home logistics network consists of the availability of hard equipment (infrastructures, machineries, etc).
There were significant constraints in the development of the questionnaire in two areas.
As for burial, Islamic scholarship holds that burial can be done anywhere while socio-custom, tradition and local socio-economic factors, including cost of land, may exert significant constraints in practice.
Yet the Obama administration faces a significant constraint in declaring a threat to Iraqi Kurdistan a threat to US interests.
This lower limit has been a significant constraint in cosmology.
However, there are implementation difficulties, which could be a significant constraint in the future.
This finding indicates that failure in finding the herd of origin for bovine TB cases could be a significant constraint in controlling bovine TB in the U.S. since it could represent a missed opportunity to identify additional infected animals and implement control measures.
Unfortunately, since multiple process units are not frequently built in the same region or using the same technologies, and because of confidentiality concerns in contract negotiation, significant constraints exist in data collection and the ability to provide reliable statistics on complexity factors.
