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To be applied to our ODE model, it requires expanding each term of the Michaelis-Menten kinetics into corresponding elementary reactions, which will add to significant computational demand especially when we intend to simulate more than one hundred single cells.
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Given that communications occur in both directions (from CNs to BNs, and then from BNs to CNs), 570240 > 219 messages are exchanged per iteration, which imposes significant computational demands (at several levels) for the development of LDPC decoders.
In contrast, TKEO calculations can be easily implemented into the data conditioning process without a significant increase in computational demand.
Media encryption schemes relying on secret transform domains have been proposed mainly motivated by the significant reduction of the computational demand for encryption as compared to traditional transparent encryption methods and by potential capabilities in encrypted domain signal processing.
On the other hand, if the free-weighting method introduces too many free-weighting matrices in the theoretical derivation, some of them sometimes have no effect on reducing the conservatism of the obtained results; on the contrary, they mathematically complicate the system analysis and consequently lead to a significant increase in the computational demand [8].
The whole model demands significant computational resources for geometric modeling, grid generation, and numerical calculation.
The model preparation and result acquisition times were found to comprise a significant portion of the total computational demand of each model.
Restricting the explored chemical space to those compounds amenable to chemical synthesis does not lead to a significant increase in computational demands.
This leads to significant computational savings particularly in problems involving computationally demanding forward models but also improvements in accuracy.
In general, due to the relatively high computational demand of calculation of entropy in AMBER 12 and the error that may introduce significant uncertainty in the results, as well as the slight variation of substitution in genistein derivatives, the conformational entropy was not considered.
However such models require significant computational resources.
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CEO of Professional Science Editing for Scientists @ prosciediting.com