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The phrase 'significant composition' is correct and usable in written English.
You can use it when referring to a creative work that has a special meaning. For example, you might say, "The artist's significant composition spoke to me in a profound way."
Exact(14)
Already his representations reveal a realistic individualism and an intense preoccupation with significant composition and form.
You can confine most of her significant composition to the basket marked "slow, bleak, reflective ballads with lots of water imagery".
Although there were significant composition changes in the landscape over the study period configurational changes are less evident.
However, when a small amount of hydrophilic glutamic acid or lysine was added into elastin-like hydrophobic copolymers of valine, glycine, and proline, significant composition dependence was found.
Finally, the extent of segregation over time is comparable but a significant composition gradient exists across the outlet of eccentric hoppers.
Spectroscopic analysis indicated a high degree of anomalous deposition across all alloy compositions, with no significant composition differences seen between films and nanowires.
Similar(46)
But he gives the erroneous impression that Blitzstein's most significant compositions "languish in manuscript in libraries".
Reich gained global notoriety in the 70s thanks to one of his most significant compositions, Music for 18 Musicians.
The first, Biohazard 2 Original Soundtrack, is the main release and includes most of the significant compositions.
Though these additives may not be significant by composition percentage, they are very significant to the performance and use of coatings.
In actual systems, two-phase production leads to significant reservoir composition changes conditions that are best captured by CVD tests.
More suggestions(15)
substantial composition
remarkable composition
significant essay
significant formation
significant settlement
considerable composition
significant membership
noticeable composition
significant establishment
important composition
significant composer
prominent composition
significant constituency
major composition
huge composition
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com