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The phrase "significant complication" is correct and usable in written English.
You can use it when referring to a difficulty or issue that presents a challenge or impedes progress. For example, "The project has been hindered by a significant complication."
Exact(60)
For American companies, there is a significant complication.
Known as graft-versus-host, the process poses a significant complication for bone marrow transplants.
If true, this adds a significant complication to this fall's confrontations.
Atelectasis is a significant complication after cardiac surgery.
Voice alteration remains a significant complication of thyroid surgery.
The most significant complication is bleeding that requires manual compression.
Osteoradionecrosis is a significant complication following head and neck radiotherapy.
However, intraoperative esophageal perforation remains a significant complication.
Bleeding is a significant complication of anticoagulant and antiplatelet medications.
Although uncommon, infection is a significant complication of intra-articular steroid administration.
Fungal infection can be a significant complication for the critically ill neonate.
More suggestions(15)
considerable complication
significant problem
noteworthy complication
significant difficulty
significant distress
significant matter
substantial complication
huge complication
tremendous complication
significant challenge
prominent complication
notable complication
significant complicating
major complication
remarkable complication
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com